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The top 10 leading causes of death in men over 40
HEART
DISEASE
Each year, about 1.1 million Americans
suffer a heart attack. About 460,000 of those heart attacks
are fatal. Heart disease is the most significant health
threat to men in the United States today. According to the
American Heart Association, men have a greater risk of heart
disease and have heart attacks much earlier in life than
women. Even after menopause, when heart disease becomes
the leading cause of death in women, the risk for men is
still greater. All men need to take this disease seriously,
and understand that their No. 1 killer often can be prevented.
Reduce Your Risk Of Heart Disease:
- Don't smoke
- Reduce high blood cholesterol
- Lower high blood pressure
- Exercise regularly
- Eat a balanced diet
- Avoid stress
- Drink alcohol moderately
- Manage diabetes
Heart Attack Warning Signs:
- Uncomfortable pressure, fullness, squeezing
or pain in the center of the chest lasting more than a
few minutes
- Pain spreading to the shoulders, neck,
arms or jaw
- Chest discomfort with lightheadedness,
fainting, sweating.
- Nausea or shortness of breath
- Atypical chest pain, stomach or abdominal
pain
- Weakness or fatigue
- Unexplained anxiety
- Palpitations, cold sweat or paleness
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CANCER
According to the American Cancer Society
(ACS), the most common cause of cancer death in U.S. men
is lung cancer. It's estimated that 90 percent of these
deaths are linked to cigarette smoking. Prostate cancer
is the second leading cause of cancer death in U.S. men,
and it's estimated that 180,400 men were diagnosed with
prostate cancer in 2000. The third leading cause of cancer
death in U.S. men is colorectal cancer. Although it's thought
that increased colorectal screening accounts for fewer male
deaths due to colorectal cancer, this type of cancer is
still a major health threat for men. It's estimated that
about one-third of all cancer deaths are related to nutrition
or other controllable lifestyle factors.
Reduce Your Risk Of Cancer:
Don't smoke or chew tobacco
Exercise regularly
Eat a diet high in fruits and vegetables
Avoid the sun
Limit alcohol
Have regular cancer screenings
Know your family medical history
Cancer Warning Signs:
A change in bowel or bladder habits
A sore that does not heal
Unusual bleeding or discharge
Thickening or a lump in the breast or somewhere else
Chronic indigestion or swallowing problems
An obvious change in a wart or a mole
A nagging cough or hoarseness
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STROKE
Stroke is not only a top killer among
men, it's also one of the leading causes of disability in
America. About 80 percent of strokes are caused by the buildup
of fatty deposits inside the arteries. High blood pressure,
smoking, lack of exercise and a diet high in fat and cholesterol
can lead to stroke. Changes in lifestyle can help decrease
your risk. Although stroke is highly preventable, certain
risk factors, such as family history, age, gender and race
can't be controlled. I
Reduce Your Risk Of Stroke:
- · Work to control blood pressure
- · Lower cholesterol
- · Cut back on dietary fat
- · Exercise regularly
- · Discuss with your doctor the possibility
of taking a low-dose aspirin daily.
Stroke Warning Signs:
Sudden numbness or weakness of the face,
arm or leg, especially on one side of the body
Sudden confusion, trouble speaking or understanding
Sudden trouble seeing in one or both eyes
Sudden trouble walking, dizziness, loss of balance or coordination
Sudden, severe headache with no known cause
LUNG
DISEASE
Chronic lung conditions include: bronchitis,
emphysema and other lung disorders. The main cause of lung
conditions is smoking, and it's strongly associated with
lung cancer, the No. 1 cause of cancer death in men. A man
who smokes is 10 times more likely to die from lung disease
than a man who does not smoke. The quality of life for someone
with lung disease diminishes as the disease progresses.
Breathlessness and activity limitations develop, and eventually
breathing may only be possible with mechanical respiratory
assistance.
Reduce Your Risk Of Lung Disease:
· DON'T SMOKE!
Lung Disease Warning Signs:
Chronic Cough
Shortness of Breath
Chronic Phlegm Production
Wheezing.
Coughing Up Blood (Hemoptysis)
Frequent Chest
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PNEUMONIA AND
INFLUENZA
Pneumonia and influenza combined are a
leading cause of death in U.S. men today. Especially when
associated with other chronic health conditions, pneumonia
and influenza can be life threatening. People with lung
conditions, asthma, heart disease, diabetes or other conditions
that suppress the immune system are at high risk. Because
both pneumonia and influenza affect the lungs, smoking can
significantly increase the effects and danger of pneumonia
and influenza. The risk of both pneumonia and influenza
can be reduced by immunizations. A yearly flu shot can be
up to 90 percent effective in preventing influenza in healthy
adults. The pneumococcal vaccine can reduce the risk of
getting pneumonia by 80 percent.
Reduce Your Risk Of Pneumonia & Influenza:
· Don't smoke
· Get a yearly flu shot
Warning Signs Of Pneumonia & Influenza:
Pneumonia:
- · Coughing
- · Fever
- · Chills
- · Chest pain
Influenza:
- · Fever
- · Headache
- · Cough
- · Sore throat
- · Nasal congestion
- · Muscle aches
- · General malaise
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DIABETES
Diabetes is a chronic disease that has
no cure. Advanced diabetes can cause blindness, kidney disease
and severe nerve damage. People with diabetes are also two
to four times more likely to have heart disease and suffer
from stroke. If you have a parent who developed diabetes
in adulthood, your risk can be up to 50 percent higher.
As the rate of obesity increases in the United States, so
does the incidence of diabetes. The most common form of
diabetes is type 2 diabetes. This form of diabetes generally
develops after age 40 and affects up to 95 percent of adults
who have the disease.
Reduce Your Risk Of Diabetes
Maintain a healthy weight
Eat healthy
Exercise regularly
Diabetes Warning Signs:
- Frequent urination (in large quantities)
- Excessive thirst
- Extreme hunger
- Rapid weight loss
- Fatigue (weak and tired)
- Irritability and mood changes
- Nausea and vomiting
- High amounts of sugar in the blood and/or urine
- Blurred vision
- Tingling or numbness in the legs, feet or fingers
- Frequent infections of the skin
- Recurring skin, gum or urinary tract infections
- Itching of skin and/or genitals
- Drowsiness
- Slow healing of cuts and bruises
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LIVER
DISEASE
Liver disease and cirrhosis (permanent
injury or scarring of the liver) combined are among the
top ten leading causes of death in U.S. men today. Diseases
of the liver often cause no symptoms, and can be due to
a number of factors including hepatitis, certain inherited
diseases and alcoholism. Excessive drinking can cause a
condition known as fatty liver and can eventually lead to
liver disease, cirrhosis and liver failure. The most effective
treatment for liver failure is a liver transplant.
Reduce Your Risk Of Liver Disease:
Receive a vaccine for hepatitis
Avoid excessive use of alcohol
Eat a low-fat diet
Avoid iv drug use, body piercing and tattooing with non-sterile
equipment
Practice safe sex
Know your family medical history
SUICIDE
Men are four times more likely than women
to die of suicide. The most important risk factor for suicide
is mental illness such as depression. Other factors include
a family history of suicide attempt, substance abuse disorders,
social adjustment problems, loneliness, grief, divorce and
unemployment. If you think you or someone you know is suicidal,
get help immediately. Early detection and treatment are
crucial in preventing someone from taking his or her own
life.
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Conditions
Men Get, Too
by John Henkel, Food & Drug Administration
Seymour Kramer noticed a patch of what
looked like blood on his pajama top three years ago and
thought he had cut himself. But he wasn't scratched. His
doctor tested the discharge and told the New Jersey man
he had breast cancer.
Dan, 70, a retired Michigan engineer who
asked that his last name not be used, was pulling weeds
three years ago. For no apparent reason, he fractured two
vertebrae. Doctors told him his bones were wasting away.
He has osteoporosis.
As a teenager, Gary Grahl was obsessed
with having a trim, "athletic" body. The Wisconsin resident
shunned food and exercised excessively. Sometimes he'd do
situps and pushups for three hours before school. He ate
little and shrank from 160 to an unhealthy 104 pounds. Over
a six-year period, he was hospitalized four times. Now 26,
Grahl says he is "completely recovered" from his eating
disorder.
What do these men have in common? They
all suffer from illnesses typically thought of as "women's
diseases." Breast cancer, osteoporosis, and eating disorders
all occur in men, too, though their prevalence is much greater
in the female population. As a result, many men, unaware
that the diseases affect both sexes, may fail to recognize
symptoms. Likewise, doctors and families often don't suspect
these illnesses. This can delay therapy and make disorders
difficult to treat.
Medical experts say men may shy away from
seeking medical treatment for disorders they feel are unmasculine.
In support groups, men use terms like "very scared" and
"ashamed" to describe initial feelings about their illnesses.
Others express frustration at the difficulty in finding
information and therapy.
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Osteoporosis
High on the list of such conditions is
osteoporosis. Though women are four times more likely to
acquire it, about 5 million men in this country have osteoporosis,
according to the National Osteoporosis Foundation. A disorder
in which bones become weakened, osteoporosis is sometimes
called the "silent disease" because it has no symptoms.
It often manifests itself in fractures of the hip, wrist,
spine, and other bones. Among both sexes, it is responsible
for 1.5 million fractures a year. Scientists are still piecing
together just how osteoporosis develops, but it is well
known that a key factor is deficiency of the mineral calcium.
Leo Lutwak, M.D., Ph.D., a medical officer in FDA's Center
for Drug Evaluation and Research, emphasizes that calcium
intake over a person's lifetime is crucial to preventing
bone loss. Ideally, he says, a diet adequate in calcium
starting in childhood "can maximize peak bone mass," helping
to ensure strong bones and make osteoporosis less likely.
The revised food label that went into effect in 1994 can
help consumers pinpoint calcium-rich foods (see the May
1993 issue of FDA Consumer).
About 99 percent of the body's calcium
is stored in bones and teeth. Bone is continually being
broken down and rebuilt. If the amount of calcium absorbed
equals the amount lost, a state of balance occurs. When
calcium absorption is greater than losses, the body accrues
a "positive balance" that it can use for bone growth and
repair. But when dietary intake of calcium can't meet the
body's needs, the body draws the mineral from bones to allow
a constant bloodstream supply. Ultimately, the breakdown
process can exceed deposits, causing a possible reduction
in bone mass and density.
Osteoporosis is seen less often in men
than in women for several reasons. Men generally have greater
bone mass than women, and in males, bone loss begins later
and advances more slowly. But men do have a hormonal drop-off
in testosterone similar to women's reduction of estrogen
after menopause. Testosterone may diminish as a result of
hypogonadism, a condition marked by decreased function of
the testicles. Testosterone levels may naturally become
lower as a man ages.
"Loss of sex hormone results in accelerated
bone loss in whomever it occurs, whenever it occurs, for
whatever reason," says Michael Kleerekoper, M.D., deputy
associate chairman of internal medicine at Wayne State University.
"Whether that translates to osteoporosis depends on how
much bone you have when the loss begins and how quickly
you lose it." Women find relief from osteoporosis with estrogen
therapy, and some men respond to testosterone injections.
But successes with hormone therapy come most often from
"seeing young men in the early stages" of the condition,
Kleerekoper says.
Another therapy shown to slow bone breakdown
and reduce pain associated with fractures attributed to
osteoporosis is the drug calcitonin, marketed as Miacalcin
or Calcimar. FDA has not approved these drugs specifically
for men, though some doctors prescribe them to males if
they feel the patient will benefit. Currently under study
for osteoporosis treatment are sodium fluoride, which some
researchers think may help increase bone mass; vitamin D,
which helps the body absorb calcium; and a nasal spray version
of calcitonin.
Dan, the Michigan osteoporosis patient,
receives biweekly testosterone injections and takes daily
supplements of 1,500 milligrams of calcium with vitamin
D. He also exercises in a swimming pool, where water provides
a beneficial resistance to movement. He says his two fractured
vertebrae three years ago made him realize that osteoporosis
gives no warnings.
Factors that raise the risk of osteoporosis
include cigarette smoking, alcohol consumption in excess
of two drinks a day, advanced age, and an inactive lifestyle.
Eric, 45, says years of inactivity helped
bring on his osteoporosis. In his early 20s, the New York
resident (who asked that his last name not be used) had
several sports accidents that seriously impaired his mobility.
An eating disorder in college also encouraged development
of the condition, he suspects. Now, his bone loss is so
severe that "anytime I have an x-ray, the doctors go into
shock," he says. He risks injury by simply taking a walk
and cannot stand barefoot on a hard floor without excruciating
pain. He is taking calcitonin, which he hopes will stabilize
his bone loss and allow him to do more walking.
Though osteoporosis cannot be cured, it
can be slowed down and steps can be taken to prevent it.
The National Osteoporosis Foundation suggests these preventive
measures:
* Eat a balanced diet rich in calcium.
* Exercise regularly, especially in weight-bearing activities.
* Don't smoke.
* If you drink alcohol, do so in moderation.
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Breast Cancer
Primarily associated with women, breast
cancer also occurs in men, although rarely. According to
the American Cancer Society (ACS), men will make up 1,400
of the 183,400 new cases of breast cancer expected in 1995.
Men typically do not perform breast self-examinations
to detect tumors, and doctors do not ordinarily examine
men for breast cancer during physicals. Unlike women, men
do not get routine mammograms. Consequently, a tumor may
be present and go undiscovered.
As with breast cancer in women, symptoms
include the presence of a breast lump that is usually firm
and painless. The nipple can have an abnormality such as
retraction, crusting, or a discharge. Patients frequently
are over 60.
Seymour Kramer was 70 when a gooey, bloodlike
discharge from his nipple prompted him to seek medical attention.
After analyzing the secretion, doctors told him he had breast
cancer and recommended a lumpectomy, in which the nipple
and a small amount of breast tissue are taken out. He also
had several lymph nodes removed, and he underwent five weeks
of radiation therapy to help ensure that residual cancer
cells were killed. Though his prognosis appears very good,
Kramer won't say he's been cured. But he expresses optimism:
"Just because I had cancer doesn't mean my life is over."
The ACS says risk factors for male breast
cancer include:
* hyperestrogenism, or abnormal secretion of the hormone
estrogen
* Klinefelter's syndrome, a male disorder characterized
by reduced or absent sperm production, small testicles,
and enlarged breasts
* gynecomastia, or enlargement of the male breast.
Though medical professionals typically
don't recommend detection exams for the general male population,
doctors may advise men with gynecomastia to perform periodic
breast self-examinations.
Because in men the disease is often detected
at an advanced stage when the tumor has spread, radical
mastectomy--removal of breast tissue and pectoral muscle--is
often the initial treatment. But if the cancer is found
before it spreads to surrounding tissue or to the lymph
nodes, a lumpectomy can be performed. Radiation sometimes
is used without surgery, but the verdict is still out on
its effectiveness. As in Kramer's case, radiation also can
be employed after surgery to reduce the chance of local
recurrence and to relieve symptoms in advanced cases. If
cancer has spread into the lymph nodes, some physicians
use chemotherapy. A therapeutic "tumor vaccine" for men
and women to treat breast cancer that has already spread
is in clinical trials now.
Possible complications after surgery or
radiation include decreased shoulder function, fluid retention
in the arm, and pain or stiffness in the operated or radiated
area. The ACS emphasizes that besides tending to the physical
consequences of breast cancer therapy, "attention should
be paid to the psychological aftereffects."
Patients also need follow-up monitoring--including
regular exams, blood chemistry, imaging (such as magnetic
resonance imaging), and bone scans--to discover any recurring
tumors quickly.
Kramer says his experience of being blindsided
by the disease put him on "a crusade" to inform men and
medical professionals about breast cancer in males. "During
a routine physical exam, I think doctors should run their
hands across a man's breast to see if there's anything irregular,"
he says. "I'm not saying men have to go out and get wholesale
mammograms. But [as a rule] doctors don't do this [touch
test] and men don't inspect themselves. Those men who are
not aware need to be shocked into the fact that, 'Hey, guys,
this could happen to you.'"
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Eating Disorders
Though many people associate eating disorders
with women, these illnesses also occur in males. In one
disorder, anorexia nervosa, the person limits food intake
to the point of starvation. In another, bulimia nervosa,
sufferers alternate between eating large amounts of food
and ridding the body of it through vomiting or laxative
use. About half of those with anorexia also have bulimia
symptoms.
According to the National Association of
Anorexia Nervosa and Associated Disorders (ANAD), men make
up about 1 million of the 8 million Americans with eating
disorders.
"It's a myth that these are illnesses of
rich, white, perfectionist women," says Chris Athas, ANAD
vice president. "Just as a man or woman may become an alcoholic,
either may fall victim to an eating disorder."
Medical professionals say the disorders
most often surface during the teen years, but in rare cases,
men as old as 60 and boys as young as 8 can be afflicted.
In both sexes, the illnesses can lead to lifelong medical
and psychological complications. An estimated 6 percent
of cases result in death. Most people find it difficult
to halt the behavior without professional assistance. Though
some men ultimately seek help, many continue untreated with
the disorders, often for years, and sometimes for a decade
or more.
Diagnosis is complicated by a reluctance
some men have to seek medical help for disorders that are
"still primarily women's," Athas says. "We live in a 'macho'
society. Many men simply are ashamed to have an illness
of this type." Thus, they suffer in silence.
Another problem, says ANAD, is that a great
number of doctors and health-care professionals are not
trained to identify or treat male eating disorders, especially
anorexia. Families, too, often fail to see the diseases'
symptoms. The illnesses then can progress to a more advanced
stage where they are harder to treat.
During recovery, men sometimes are unwilling
to participate in support-group sessions because the groups
are mostly female. "Men as a whole are not comfortable in
eating disorder support groups," says Athas. "But we encourage
them to go anyway."
Unlike many women, who acquire eating disorders
because they "feel" fat, men often are medically obese at
some point in the illness and feel pressure to be thin.
Sometimes athletic activities induce this struggle to be
lean, prompting not only the eating disorder but also compulsive
exercising. Men also may adopt disease behaviors when teased
or criticized about being fat at critical development stages,
such as puberty.
Treatment can be very effective, according
to Arnold Andersen, M.D., an expert on eating disorders
in men who has written a book on the subject. He describes
a regimen of inpatient or outpatient hospital treatment,
depending on the illness severity. Conditions such as anemia
or depression are treated, and patients gradually relearn
proper eating habits. Treatment also usually includes psychotherapy,
which helps patients understand why they have the illness.
One antidepressant drug, Prozac (fluoxetine
hydrochloride), is under review by FDA as a treatment for
bulimia. Other antidepressants also are being studied. One,
Wellbutrin (bupropion), was shown to induce seizures in
both anorexia and bulimia patients. Doctors sometimes prescribe
tricyclic drugs--a class that includes Elavil (amitriptyline),
Tofranil (imipramine), and Norpramin (desipramine). FDA
has approved tricyclics for other uses but not specifically
for eating disorders. However, doctors may prescribe approved
drugs for "off-label" uses if, in their judgment, the patient
will benefit.
Patients also undergo what Andersen calls
"nutritional rehabilitation," which allows them to regain
a desirable body weight. Treatment is followed by weeks,
months, even years of follow-up to ensure complete recovery.
Men in support groups for eating disorders,
as well as those for breast cancer and osteoporosis, say
the public gradually is becoming more aware that these disorders
can occur in men. They also say there's a long way to go.
Some think doctors need to be enlightened. Others bemoan
the lack of research. But most seem to agree that men should
be educated about the disorders and how to detect them.
As breast cancer patient Seymour Kramer
says: "Men need to get the word that, yes, this is a woman's
disease. But you're not immune. It can happen to you."
John Henkel is a staff writer for FDA Consumer.
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